Our interdisciplinary research program

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Our interdisciplinary program La dynamique du vieillir (The dynamics of aging) is concerned by all aspects of the aging process. Its main goal is to provide, through an improved knowledge of aging phenomena,  operational tools to improve the quality of life of elderly people, with a particular focus on the characterization and detection of frailty conditions. This ambitious program combines basic research, technological developments and also concerns organisational, social (acceptability) and economic issues to address the problem of the aging of the population. It gathers in this common ambition researchers and practitioners from very different areas : physicists, biologists, neurophysiologists, geriatricians and gerontologists, nutritionists, psychologists, neuropsycholo­gists, economists, sociologists, philosophers, psychoanalysts. More than 15 research laboratories and 8 hospital units (geriatry and psychiatry) representing a community of about 50 researchers participate to the program.

The program has three main areas of focus:

1. The quantitative measurement of aging and frailty, on a wide range of animals (bacteria E. coli, nematode worms C. elegans, mice, mouse lemurs Microcebus murinus) and on human cohorts; the determination of new biomarkers of aging and frailty

2. The study of the age-related changes of people in their abilities and potential throughout life, using new technologies such as virtual reality, smart bracelets, smart apartments with the aim of rehabilitation or compensation of the loss of autonomy;

3. The study of devices and organizations to ease the identification of fragile or vulnerable elderly persons, of the conditions favoring their social and economic acceptability and the development of new innovative responses in different field contexts (with a particular focus on the Reunion island, a French departement, in the Indian Ocean).

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Our recent bibliography:

  1. Djelti, F., Dhenain, M., Terrien, J., Picq, J. L., Hardy, I., Champeval, D., … & Aujard, F. (2017). Impaired fasting blood glucose is associated to cognitive impairment and cerebral atrophy in middle-aged non-human primates. Aging (Albany NY), 9(1), 173. Page
  2. Marck, A., Berthelot, G., Foulonneau, V., Marc, A., Antero-Jacquemin, J., Noirez, P., … & Toussaint, J-F. (2016). Age-Related Changes in Locomotor Performance Reveal a Similar Pattern for Caenorhabditis elegans, Mus domesticus, Canis familiaris, Equus caballus, and Homo sapiens. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, glw136. Page
  3. La Corte, V., Sperduti, M., Malherbe, C., Vialatte, F., Lion, S., Gallarda, T., … & Piolino, P. (2016). Cognitive decline and reorganization of functional connectivity in healthy aging: the pivotal role of the salience network in the prediction of age and cognitive performances. Frontiers in Aging Neuroscience, 8Page
  4. La Corte, V., & Piolino, P. (2016). On the role of personal semantic memory and temporal distance in episodic future thinking: the TEDIFT model. Frontiers in Human Neuroscience, 10Page
  5. Le Garrec, G., & Touzé, V. (2016). Capital accumulation and the dynamics of secular stagnation (No. 2016-17). Observatoire Francais des Conjonctures Economiques (OFCE). Page
  6. Gannon, F., Le Garrec, G., & Touzé, V. (2016). Aging, International Capital Flows and Long&Run Convergence (No. 2016-09). Observatoire Francais des Conjonctures Economiques (OFCE). Page
  7. Barrois, R., Gregory, T., Oudre, L., Moreau, T., Truong, C., Pulini, A. A., … & Yelnik, A. (2016). An Automated Recording Method in Clinical Consultation to Rate the Limp in Lower Limb Osteoarthritis. PLoS One, 11(10), e0164975.Page
  8. Chiarovano, E., Vidal, P. P., Magnani, C., Lamas, G., Curthoys, I. S., & de Waele, C. (2016). Absence of rotation perception during warm water caloric irrigation in some seniors with postural instability. Frontiers in neurology, 7Page
  9. Desgorces, F. D., Thomasson, R., Aboueb, S., Toussaint, J. F., & Noirez, P. (2015). Prediction of one-repetition maximum from submaximal ratings of perceived exertion in older adults pre-and post-training. Aging clinical and experimental research, 27(5), 603-609. Page
  10. Barrois, R., Oudre, L., Moreau, T., Truong, C., Vayatis, N., Buffat, S., … & Vidal, P. P. (2015). Quantify osteoarthritis gait at the doctor’s office: a simple pelvis accelerometer based method independent from footwear and aging. Computer methods in biomechanics and biomedical engineering, 18(sup1), 1880-1881. Page
  11. da Silva Antero-Jacquemin, J., Berthelot, G., Marck, A., Noirez, P., Latouche, A., & Toussaint, J. F. (2015). Learning from leaders: life-span trends in Olympians and supercentenarians. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences, 70(8), 944-949. Page
  12. Manière, X., Krisko, A., Pellay, F. X., Di Meglio, J. M., Hersen, P., & Matic, I. (2014). High transcript levels of heat-shock genes are associated with shorter lifespan of Caenorhabditis elegans. Experimental Gerontology, 60, 12–17. Page
  13. Gannon, F., Hamayon, S., Legros, F., & Touzé, V. (2014). Sustainability of the French first pillar pension scheme (CNAV): assessing automatic balance mechanisms. Page